Chemiluminescent dialkyl-substituted 1,2-dioxetanes, methods of

Details Chemiluminescent dialkyl-substituted 1,2-dioxetanes, methods of Chemiluminescent dialkyl-substituted 1,2-dioxetanes, methods of

1997-11-26

1999-04-06

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549214, 549218, 549511, 536 41, C07D30500, C07F 702, C07F 906

Patent

active

058920641

ABSTRACT:
A chemiluminescent assay method and compositions are described which use a dialkyl-substituted dioxetane which is deprotected to trigger a chemiluminescent reaction. Chemiluminescent 1,2-dioxetane compounds substituted on the dioxetane ring with two nonspirofused alkyl groups which can be triggered by a reagent to generate light are disclosed. Dialkyl-substituted dioxetanes are useful for the detection of triggering agents including enzymes. The enzyme may be present alone or linked to a member of a specific binding pair in an immunoassay, DNA probe assay or other assay where the enzyme is bound to a reporter molecule.

REFERENCES:
patent: 5650525 (1997-07-01), Matsumoto
patent: 5721370 (1998-02-01), Akhavan-Tafti et al.
patent: 5777133 (1998-07-01), Bronstein et al.
patent: 5777135 (1998-07-01), Akhavan-Tafti et al.
Matsumoto, M. et al `Synthesis and chemiluminescence of 3-biphenyl-4,4-dusopropyl-3-methoxy-1,2-dioxetane` CA 124: 956546, 1995.

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