Human rhombotin-like protein

Details Human rhombotin-like protein Human rhombotin-like protein

1996-12-27

1999-04-06

Huff, Sheela

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, 514 44, 435 6, 4353201, 530324, C07H 2104, A01N 4304, C12Q 168, A61K 3800

Patent

active

058920153

ABSTRACT:
The present invention provides a human rhombotin-like protein (RBTNH) and polynucleotides which identify and encode RBTNH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding RBTNH and a method for producing RBTNH. The invention also provides for agonists, antibodies, or antagonists specifically binding RBTNH, and their use, in the prevention and treatment of diseases associated with expression of RBTNH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding RBTNH for the treatment of diseases associated with the expression of RBTNH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding RBTNH.

REFERENCES:
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Fisch, P. et al., "T-cell acute lymphoblastic lymphoma induced in transgenic mice by the RBTN1 and RBTN2 LIM-domain genes," 1992, Oncogene 7:2389-2397.
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Database, EMBL-EMHUM1, Entry HS245761, GenBank Accession No. U24576, May 5, 1995.

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