Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-12-06
1999-04-06
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 19, 514213, 514214, 514221, 514361, 514362, 514363, 514364, 514383, 530331, 540500, 540508, 540510, 540520, 540523, 548128, 548131, 548136, 548143, A61K 3805, A61K 3806, C07K 5078, C07K 5097
Patent
active
058918523
ABSTRACT:
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cystic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, corneal ulcers, and invasion behavior of malignant tumors.
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Gyorkos Albert
Spruce Lyle W.
Cortech Inc.
Russel Jeffrey E.
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