Sulfonamido derivative inhibiting the aldose reductase enzyme sy

Details Sulfonamido derivative inhibiting the aldose reductase enzyme sy Sulfonamido derivative inhibiting the aldose reductase enzyme sy

1990-02-08

1991-11-19

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562430, A61K 3119, C07C31714

Patent

active

050666762

ABSTRACT:
The xanthosulfonamido and benzensulfonamido derivatives corresponding to the formula: ##STR1## wherein X represents hydrogen, alkyl, alkoxy or halogen, Y represents an alkyl, alkoxy or halogen and Z represents the group ##STR2## or Y and Z taken together form the group: ##STR3## wherein R.sub.1 in turn is a group selected among electron attracting groups, halogens and the group: ##STR4## itself, possess activity in inhibiting the aldose-reductase enzyme system and are thus useful in the treatment of the complications, at the eye and peripheral neuropathy levels, as induced by diabetes.

REFERENCES:
patent: 4113463 (1978-09-01), Oshio et al.

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