Process for the preparation of 2-amino-5-aminomethyl-pyridine

Details Process for the preparation of 2-amino-5-aminomethyl-pyridine Process for the preparation of 2-amino-5-aminomethyl-pyridine

1994-01-11

1995-12-26

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546289, 546193, 544124, 544360, C07D21309, C07D21102, C07D41304, C07D40304

Patent

active

054789443

ABSTRACT:
2-Amino-5-aminomethyl-pyridine, of the formula ##STR1## can be prepared by reacting substituted methylene-glutaconic acid dinitrile of the formula ##STR2## having the meaning of R.sup.1 as given in the general description, at from 50.degree. to 200.degree. C., initially with from 3 to 20 mol of ammonia and then, in the presence of a hydrogenation catalyst, with hydrogen. The hydrogen is present an a partial pressure of from 10 to 250 bar. The reaction can be carried out with or without solvent.

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1962 Interscience Publishers, Erwin Klingsberg, "Pyridine and its derivatives, Part Three" cover page ' pp. 68-69; Oct. 29, 1973.
Science, American Association for the Advancement of Science, Oct. 3, 1969, vol. 166, No. 3901; "Photochemical Reactions and the Chemical Evolution of Purines and Nicotinamide Derivatives"; cover page + pp. 765-766 (Nov. 7, 1969).

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