Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1990-01-26
1991-11-19
Lacey, David L.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4351723, 435287, 935 53, 935 85, C12N 1589, C12M 100
Patent
active
050665871
ABSTRACT:
A foreign substance, such as DNA, is injected into plant cells or tissue by a biological ballistical insertion technique. High pressure propellant gas is employed to accelerate the macroprojectile containing microprojectiles coated with the foreign substance. A movable macroprojectile stop mechanism is provided between an upper injection chamber and a lower sample-holding chamber so that multiple shots of macroprojectiles can be made without disrupting the vacuum in the lower chamber. The stop mechanism includes removable stopper plugs for stopping the macroprojectile. A vacuum seal is provided between the stop mechanism and the lower chamber.
REFERENCES:
patent: 3343400 (1967-09-01), Rogers et al.
patent: 3404599 (1968-10-01), Annis
patent: 4945050 (1990-07-01), Sanford et al.
Klein et al., "High-Velocity Microprojectiles for Delivering Nucleic Acids Into Living Cells", Nature, vol. 327 (May 7, 1987), pp. 70-73.
Klein et al., "Factors Influencing Gene Delivery Into Zea Mays Cells by High-Velocity Microprojectiles", Bio/Technology, vol. 6 (May 1988), pp. 559-563.
McCabe et al., "Stable Transformation of Soybean (Glycine Max) by Particle Acceleration", Bio/Technology, vol. 6 (Aug. 1988), pp. 923-926.
Marikawa et al., "Transient Expression of Foreign Genes in Plant Cells and Tissues Obtained by a Simple Biolistic Device", Applied Microbiology and Biotechnology, vol. 31 (1989), pp. 320-322.
Chee Paula P.
Frey Paul T.
Gleason David D.
Jones Lawrence D.
Slightom Jerry L.
Beisner William H.
Lacey David L.
The Upjohn Company
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