Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1988-04-11
1991-11-19
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514823, 514922, A61K 4900
Patent
active
050664808
ABSTRACT:
A method is provided for preventing reducing or reversing adverse reactions, such as pulmonary hypertension produced when protamine interacts with heparin, by administering a thromboxane A.sub.2 receptor antagonist.
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Morel et al., Chem. Abst. 107(5): 37778p (1987).
The Merck Manual, pp. 2514-2515, (1987).
Degges et al., "Pulmonary Hypertensive Effect of Heparin and Protamine Interaction; Evidence for Thromboxane B.sub.2 Release from Lung", Am. Jour. Surg., vol. 154, pp. 696-699, Dec. 1987.
Schumacher et al., "Effect of the Thromboxane A.sub.2 Receptor Antagonist, SQ 29,548 and SQ 28,668, on the Pulmonary Hypertensive Response to Endotoxemia in Swine", Pharm. 34: 301-308 (1987).
Friedhoff Lawrence T.
Grover Gary J.
Ogletree Martin L.
Schumacher William A.
E. R. Squibb & Sons Inc.
Hollinden Gary E.
Hollrah Glennon H.
Rodney Burton
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