Control of calcium fluoride formation in mouth rinses, dentifric

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form

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424468, 424464, 424 48, 424 49, 424 52, A61K 900

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active

058914480

ABSTRACT:
Specific compositions and methods are disclosed employing calcium fluoride inhibitors in two-component fluoride delivery systems to produce an initial delay in calcium fluoride formation and to control the rate of reactions that precipitate calcium fluoride in order to achieve enhanced fluoride deposition in the oral environment. In the two-component fluoride delivery system, one component contains a source of calcium ions and the other a source of fluoride ions. An inhibitor of calcium fluoride formation is present in one or both phases such that when one or both components are mixed the formation of calcium fluoride precipitate does not occur until at least about five seconds after mixing. The system may be employed in the form of mouth rinses, dentifrices, or chewable tablets.

REFERENCES:
patent: 3966863 (1976-06-01), Forward et al.
patent: 4048300 (1977-09-01), Tomlinson et al.
patent: 4080440 (1978-03-01), Dibiulio et al.
patent: 4083955 (1978-04-01), Grabenstetter et al.
patent: 4108980 (1978-08-01), Duff
patent: 4177258 (1979-12-01), Gaffar et al.
patent: 4183915 (1980-01-01), Gaffar et al.
patent: 4283385 (1981-08-01), Dhabhar et al.
patent: 4348381 (1981-09-01), Gaffar
patent: 4397837 (1983-08-01), Raaf et al.
patent: 4420312 (1983-12-01), Wason
patent: 4460565 (1984-07-01), Weststrate et al.
patent: 4532124 (1985-07-01), Peasce
patent: 4556561 (1985-12-01), Brown et al.
patent: 4606912 (1986-08-01), Rudy et al.
patent: 4610873 (1986-09-01), Rudy et al.
patent: 4714608 (1987-12-01), Rolla
patent: 4861590 (1989-08-01), Grodberg
patent: 5143719 (1992-09-01), Elliott et al.
patent: 5145668 (1992-09-01), Chow et al.
patent: 5310542 (1994-05-01), Av et al.
patent: 5476647 (1995-12-01), Chow et al.
Chow, L.C. and Takagi, S. (1991): Deposition of Fluoride on Tooth Surfaces by A Two-solution Mouth Rinse In Vitro. Caries Res, 25:397-401.
Chow, L.C., Takagi, S., and Shih, S. (1992): Effect of A Two-solution Fluoride Mouth Rinse on Remineralization of Enamel Lesions In Vitro, J. Dent Res, 77:443-447.
Vogel, G.L., Mao, Y., Carey, C.M., Chow, L.C. and Takagi, S. (1992): In Vivo Fluoride Concentrations Measured for Two Hours After a NaF or a New Two-Solution Rinse, J. Dent Res, 71:448-452.
Amjad, Z. (1993): Performance of Inhibitors in Calcium Fluoride Crystal Growth Inhibition, Langmuir, 9:597-600.
Grases, F., et al. (1991): A Study of the Relationship Between the Chemical Structure of Some Carboxylic Acids and Their Capacity to Inhibit the Crystal Growth of Calcium Fluoride. Colloids Surf., 54:313-319.
Grases, F., et al., (1991): Determination of Citric Acid Based on Inhibition of the Crystal Growth of Calcium Fluoride, Analyst, 116:59-63.
Amjad, Z. (1991): Constant Composition Study of Crystal Growth of Calcium Fluoride. Influence of Polycarboxylic Acids, Polyphosphates, Phosphonates, and Phytate, Langmuir, 7:600-603.
Christofferson, J., et al. (1988): Kinetics of Dissolution and Growth of Calcium Fluoride and Effects of Phosphate, Acta Odontol. Scand., 46:325-336.
Nancholas, G.H., et al. (1982): The Kinetics of Crystal Growth of Divalent Metal Fluorides, AIChE, Symp. Ser. 78:26-36.
Rolla, G. and Sazegaard, E. (1990): Critical Evaluation of The Composition and Use of Topical Fluorides, With Emphasis On The Role of Calcium Fluoride In Caries Inhibition, J Dent Res 69 (Spec Iss): 780-785.
Sieck, B; Takagi, S.; and Chow, L.C. (1990): Assessment of Loosely-bound and Firmly-bound Fluoride Uptake by Tooth Enamel From Topically Applied Fluoride Treatments, J Dent Res, 60:1261-1265.

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