Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process...
Patent
1994-08-25
1995-12-26
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
435147, 435166, 4351885, 43524027, C12P 100, C12N 900
Patent
active
054787289
ABSTRACT:
A process is disclosed by which a substrate is catalytically converted to a cis olefin via a syn elimination reaction. The catalyst is a monoclonal antibody or paratope-containing molecule that binds to the substrate as well as to a bicyclo[2.2.1]heptane or bicylo[2.2.2]octane compound that is an analogue to the substrate having its bulky substituents in eclipsed positions. The chemical reaction is carried out in an aqueous medium. The catalyst molecules and hybridoma cells that secrete those molecules are also contemplated, as is a process for using cyclopentadiene or cyclohexadiene to prepare a hapten used to induce production of the catalyst molecules.
REFERENCES:
patent: 5208152 (1993-05-01), Hilvert et al.
Cravatt, B. F., et al. (1994) J. Am. Chem. Soc. 116, 6013-6014.
Boger, D. L., et al., (1994) J. Org. Chem. 59, 5078-5079.
Janda, K. D., et al. (1993) Science 259, 490-493.
Gouverneur, V. E., et al. (1993) Science 262, 204-208.
Ashley Jon A.
Boger Dale L.
Cravatt Benjamin F.
Janda Kim D.
Lerner Richard A.
Patterson Jr. Charles L.
The Scripps Research Institute
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