Sensor arrays for detecting analytes in fluids

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

422 98, 436149, 436150, 204406, 204415, 204418, 73 2331, 73 232, 73 2334, 7333505, 324691, 324693, 338 7, 338 13, 338 14, G01N 2702

Patent

active

058913980

ABSTRACT:
Chemical sensors for detecting analytes in fluids comprise first and second conductive elements (e.g. electrical leads) electrically coupled to and separated by a chemically sensitive resistor which provides an electrical path between the conductive elements. The resistor comprises a plurality of alternating nonconductive regions (comprising a nonconductive organic polymer) and conductive regions (comprising a conductive material) transverse to the electrical path. The resistor provides a difference in resistance between the conductive elements when contacted with a fluid comprising a chemical analyte at a first concentration, than when contacted with a fluid comprising the chemical analyte at a second different concentration. Arrays of such sensors are constructed with at least two sensors having different chemically sensitive resistors providing dissimilar such differences in resistance. Variability in chemical sensitivity from sensor to sensor is provided by qualitatively or quantitatively varying the composition of the conductive and/or nonconductive regions. An electronic nose for detecting an analyte in a fluid may be constructed by using such arrays in conjunction with an electrical measuring device electrically connected to the conductive elements of each sensor.

REFERENCES:
patent: 3045198 (1962-07-01), Dolan et al.
patent: 4542640 (1985-09-01), Clifford
patent: 4631952 (1986-12-01), Donaghey
patent: 4759210 (1988-07-01), Wohltjen
patent: 4855706 (1989-08-01), Hauptly
patent: 4907441 (1990-03-01), Shurmer
patent: 4992244 (1991-02-01), Grate
patent: 5045285 (1991-09-01), Kolesar, Jr.
patent: 5120421 (1992-06-01), Glass et al.
patent: 5256574 (1993-10-01), Neuberger et al.
patent: 5417100 (1995-05-01), Miller et al.
patent: 5512882 (1996-04-01), Stetter et al.
patent: 5623212 (1997-04-01), Yamanaka
patent: 5654497 (1997-08-01), Hoffheins et al.
patent: 5675070 (1997-10-01), Gelperin
Andrieux, Claude, et al., "Observation of the Cation Radicals of Pyrrole and of Some Substituted Pyrroles in Fast-Scan Cyclic Voltammetry," Standard Potentials and Lifetimes, J. Am. Chem. Soc., 112, pp. 2439-2440 (1990) No month available.
Barlett, P.N., et al., "Electrochemical Deposition of Conducting Polymers onto Electronic Substrates for Sensor Applications," Sensors and Actuators A, A21-A23, pp. 911-914 (1990) No month available.
Bidan, G. et al., "Polypyrrole and poly(N-methylpyrrole) films doped with Keggin-type heteropolyanions: preparation and properties," J. Electroanal. Chem., 251, pp. 297-306 (1988) No month available.
Charlesworth, John, et al., "Mechanistic Studies on the Interactions between Poly(pyrrole) and Organice Vapors," J. Phys. Chem., 97, pp. 5418-5423 (1992) No month available.
Corcoran, P., et al., "Integrated tin oxide sensors of low power consumption for use in gas and odour sensing," Sensors and Actuators B, 15-16, pp. 32-37 (1993) No month available.
DeVries, Steven, et al., "Synaptic Circuitry of the Retina and Olfactory Bulb," Cell/Neuron, 72/10 (Suppl) pp. 139-149 (1993) No month available.
Diaz, A.F., et al., "Electrooxidation of Aromatic Oligomers and Conducting Polymers," J. Electr. Chem., 121, pp. 355-361 (1981) No month available.
Dickinson, Todd A., et al., "A chemical-detecting system based on a cross-reactive optical sensor array," Nature, vol. 382, No. 22, pp. 697-699, Aug. 22, 1996.
Dickinson, Todd A., et al., "Generating Sensor Diversity through Combinatorial Polymer Synthesis," Analytical Chemistry, vol. 69, No. 17, pp. 3413-3418, Sep. 1, 1997.
Gardner, Julian W., et al., "Integrated Tin Oxide Odour Sensors," Sensors and Actuators B, 4, pp. 117-121 (1991) No month available.
Gardner, Julian W., et al., "Application of an electronic nose to the discrimination of coffees," Sensors and Actuators B, 6, pp. 71-75 (1992) No month available.
Gardner, Julian W., et al., "Design of Conducting Polymer Gas Sensors: Modelling and Experiment," Synthetic Metals, vol. 55-57, pp. 3665-3670 (1993) No month available.
Gardner, Julian W., et al., "Detection of vapours and odours from a multisensor array using pattern-recognition. Part 2. Artificial Neural Networks," Sensors and Actuators B, 9, pp. 9-15 (1992) No month available.
Gardner, Julian W., et al., "Detection of vapours and odours from a multisensor array using pattern-recognition. Part 1. Principal Component and Cluster Analysis," Sensors and Actuators B, 4, pp. 109-115 (1991) No month available.
Gardner, Julian W., et al., "A multisensor system for beer flavor monitoring using an array of conducting polymer and predictive classifiers," Sensors and Actuators B, 18-19, pp. 240-243 (1994) No month available.
Gardner, Julian W., et al., "A brief history of electronic noses," Sensors and Actuators B, 18-19, pp. 211-220 (1994) No month available.
Grate, Jay W., et al., "Solubility interactions and the design of chemically selective sorbent coatings for chemical sensors and arrays," Sensors and Actuators B, 3, pp. 85-111 (1991) No month available.
Grate, Jay W., et al., "Smart Sensor System for Trace Organophosphorous and Organosulfur Vapor Detection Employing a Temperature-Controlled Array of Surface Acoustic Wave Sensors, Automated Sample Preconcentration and Pattern Recognition," Anal. Chem., 65, pp. 1868-1881 (1993) No month available.
Hecht, Mathematics in Chemistry: An Introduction to Modern Methods, Prentice Hall, Enflewood Cliffs, NJ, Ch. 5, pp. 256-335 (1990) No month available.
Johnson, Stephen R., et al., "Identification of Multiple Analytes Using an Optical Sensor Array and Pattern Recognition Neural Networks," Analytical Chemistry, vol. 69, No. 22, pp. 4641-4648, Nov. 15, 1997.
Kanzawa, K.K., et al., "Electrical Properties of Pyrrole and its Copolymers," Synthetic Metals, 4, 119-130 (1981) No month available.
Kauer, John S., "Contributions of topography and parallel processing to odor coding in the vertebrate olfactory pathway," TINS, vol. 14, No. 2, pp. 79-85 (1991) No month available.
Kaufman, J.H., et al., "Evolution of Polaron States into Bipolarons in Polypyrrole," Physical Review Letters, vol. 53, No. 19, pp. 1005-1008 (1984) No month available.
Lancet, Doron, et al., "Olfactory receptors," Current Biology, vol. 3, No. 10, pp. 668-674 (1993) No month available.
Lewis, Nathan, "The Caltech Electronic Nose Project," Engineering & Science, No. 3, pp. 3-13, 1996 No month available.
Lonergan, Mark C., et al., "Array-Based Vapor Sensing Using Chemically Sensitive, Carbon Black-Polymer Resistors," Division of Chemistry and Chemical Engineering, California Institute of Technology, XP-002078727, Chemical Material, No. 8, pp. 2298-2312, 1996 No month available.
Lonergan, Mark C., et al., "Array-Based Vapor Sensing Using Chemically Sensitive, Polymer Composite Resistors," Division of Chemistry and Chemical Engineering, California Institute of Technology, XP-002078726, pp. 583-631 No month/yr. available.
Lundstrom, I., et al., "Artificial `Olfactory` images from a chemical sensor using a light-pulse technique," Nature, vol. 352, pp. 47-50 (1991).
Morris, A.C., et al., "The System Ethanol-Methanol at 40.degree. C.," Canadian Journal of Research, vol. 20, Sec. B, pp. 207-211 (1942).
Pearce, Timothy C., et al., "Electronic Nose for Monitoring the Flavour of Beers," Analyst, vol. 118, pp. 371-377 (1993).
Pope, Heteropoly and Isopoly Oxometalates (Springer-Verlag, New York), Ch. 4, pp. 58-90 (1983).
Reed, Randall R., "Signaling Pathways in Odorant Detection," Neuron, vol. 8, pp. 205-209 (1992).
Salmon, M., et al., "A Chemical Route to Pyrrole Polymer Films," Journal of Polymer Science, 20-3, pp. 187-193 (1982).
Shurmer, Harold V., et al., "Integrated Arrays of Gas Sensors Using Conducting Polymers with Molecular Sieves," Sensors and Actuators B, 4, pp. 29-33 (1991).
Stetter, J.R., et al, "Detection of Hazardous Gases and Vapors: Pattern Recognition Analysis of Data from an Electrochemical Sensor Array," Anal. Chem., 58, pp. 860-866 (1986).
Stetter, J.R., et al., "Quality classifications of grain using a sensor array and pattern recognition," Analytica Chimica Acta, 284, pp. 1-11 (1993).
Stetter, J.R., et al.,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Sensor arrays for detecting analytes in fluids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sensor arrays for detecting analytes in fluids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sensor arrays for detecting analytes in fluids will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1368475

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.