Method for synthesis of prostaglandin derivatives

Details Method for synthesis of prostaglandin derivatives Method for synthesis of prostaglandin derivatives

1994-02-08

1994-10-25

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07C40500, C07D307935

Patent

active

053590953

ABSTRACT:
##STR1## Method for preparing 13,14-dihydro-17-phenyl analogues of PGF.sub.2.alpha. or PGE.sub.2 comprising the step of hydrogenating the double bond in an intermediate compound (1) without deoxygenation of the allylic alcohol to give one of the intermediate compounds (II, III) wherein R is hydrogen or one or more halogen, hydroxyl, cyanide, alkyl (preferably 1-4 carbon atoms). hydroxyalkyl, trifluoromethyl or aromatic or heteroaromatic substituents on the aromatic ring R.sub.1 and R.sub.2 are each hydrogen alkyl (preferably 1-4 carbon atoms), hydroxyl, halogen or hydroxyalkyl substituents, R.sub.3 is O-alkyl or N(alkyl), P is a protecting group.

REFERENCES:
patent: 3962312 (1976-06-01), Hayashi
patent: 4036832 (1977-07-01), Hess

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