Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

Details Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

1988-05-19

1989-02-28

Ceperley, Mary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514378, 548236, 548247, 548248, 548249, A61K 3142, C07D41306

Patent

active

048086010

ABSTRACT:
Certain novel 2-oxindole compounds, having an acyl substituent at both the 1-position and the 3-position, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and antiinflammatory agents in mammalian subjects. These 1,3-diacyl-2-oxindole compounds are of particular value for acute administration for ameliorating pain in human patients recovering from surgery or trauma, and also for chronic administration to human subjects for alleviating the symptoms of chronic diseases such as rheumatoid arthritis and osteoarthritis.

REFERENCES:
patent: 3462450 (1969-08-01), Shen
patent: 3519592 (1970-07-01), Holden
patent: 3551571 (1970-12-01), Pachter
patent: 3631177 (1971-12-01), Holden
patent: 3749731 (1973-07-01), Zinness et al.
patent: 3767653 (1973-10-01), Krapcho
patent: 3856967 (1974-12-01), Allais et al.
patent: 3975531 (1976-08-01), Welstead et al.
patent: 4012394 (1977-03-01), Descamps
patent: 4209521 (1980-06-01), Archibald et al.
patent: 4658037 (1987-04-01), Kadin
patent: 4690943 (1987-09-01), Kadin
Pakula et al., Chem. Abstr. 72:12563(k) (1970).
Brenner et al., Chem. Abstr. 72:12565(n) (1970).
Shen et al., Chem. Abstr. 72:12566(p) (1970).
Wenkert et al., J. Amer. Chem. Soc., vol. 80, 4899 (1958).
Bunnet et al., Org. Syntheses, vol. 40, 1 (1960).
Bruce, J. Chem. Soc. (London), p. 5302 (1962).
Tacconi et al., Tetrahedron, vol. 27, p. 561 (1971).
Kisteneva, Chem. Abstr. 51:5044(a) (1957).

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