Imidazolyl- indolylpropanones as 5-HT.sub.3 receptor antagonists

Details Imidazolyl- indolylpropanones as 5-HT.sub.3 receptor antagonists Imidazolyl- indolylpropanones as 5-HT.sub.3 receptor antagonists

1988-01-22

1989-02-28

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514323, 514397, 540603, 546201, 548336, A61K 3155, C07D40306

Patent

active

048085812

ABSTRACT:
The invention relates to compounds of formula (I): ##STR1## and physiologically acceptable salts or solvates thereof, wherein Im represents an imidazolyl group of formula: ##STR2## and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.

REFERENCES:
patent: 4619941 (1986-10-01), Wright et al.
patent: 4695578 (1987-09-01), Coates et al.
P. G. Baraldi et al., Chem. Abs., 1981, 94:84484n (Farmaco, Ed. Sci., 1980, 35(8), 698-705).

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