P-anisoyl streptokinase/plasminogen complex

Details P-anisoyl streptokinase/plasminogen complex P-anisoyl streptokinase/plasminogen complex

1986-08-29

1989-02-28

Naff, David M.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

424 9464, 435174, 435188, 435216, 514802, A61K 3747, A61K 37547, C12N 1100, C12N 970

Patent

active

048084050

ABSTRACT:
A binary complex between streptokinase and plasminogen is prepared in which the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis such that the pseudo-first order rate constant for hydrolysis of the complex is in the range 10.sup.-6 sec.sup.-1 to 10.sup.-3 sec.sup.-1 in isotonic aqueous media at pH 7.4 at 37.degree. C. The complex is preferably a p-anisoyl streptokinase/plasminogen complex without internal peptide bond cleavage. The complex is useful in the treatment of venous thrombosis.

REFERENCES:
patent: 4082612 (1978-04-01), Robbins et al.
patent: 4178368 (1979-12-01), Heimburger et al.
patent: 4285932 (1981-08-01), Smith
McClintock et al., Biochemical and Biophysical Research Communications, vol. 43, No. 3, 1971, pp. 694-702.
Buck et al., J. Biol. Chem., 243, 3648-3654 (1968).
Chase, Jr. et al., Biochem., 8, 2212-2224 (1969).
McClintock et al., Biochem., 13, 5334-5344 (1974).
Markus et al., J. Biol. Chem., 251, 6495 (1976).
Brockaway et al., Biochem., 13, 2063-2069 (1974).
Abstract P5-076 0929, Thrombosis & Haemostasis, (Stuttgart), 42, 390 (1979).

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