Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1986-12-11
1989-02-28
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
514953, 514964, A61K 922, A61K 924, A61K 926, A61K 952, G01N 100, G01N 348
Patent
active
048083992
ABSTRACT:
The present invention pertains to a preparation for diagnosing the transport function of the fallopian tube and to a method for making such a preparation.
The diagnostic preparation for investigation of the transport function of female fallopian tube, comprises a suspension of a biocompatible, biodegradable, and, if desired, labelled particles, in a vehicle commonly used for parenteral applications wherein the particles have a spherical shape with diameters in the region 10 to 600 um, which are formed from a soft hydrophilic gel based on a polymer selected from the group comprising additionally crosslinked water-soluble nontoxic and biodegradable inert polysaccharides and physiologically inert water-soluble and biodegradable poly(amino acids), polypeptides, and their derivatives, which may contain physiologically active substances. The particles retain their shape and size in the environment of peritoneal cavity and uterotubal tract for at least 80 hours with the subsequent degradation to nontoxic product within 5 to 60 days.
A method for preparation of the diagnostic preparation comprises dispersing an aqueous solution of physilogically inert, biodegradable polymer selected from the group of polysaccharides, poly(amino acids), polypeptides, and their derivatives, in a medium of nonpolar water-immiscible solvent, to 10 wt. % of the polymer having a degree of polymerization of 50 to 500, said suspension containing of 80 to 100 mol. % of .gamma.-alkyl-L-glutamate units and 0 to 20 mol. % units of L-glutamic acid, units as a suspension stabilizer, with mixing sufficient to form polymeric spherical particles with diameter 100 to 600 um, which are transferred into the gel state with bifunctional crosslinking agents. The particles are washed and then dispersed in an aqueous solution. The resulting suspension is then sterilized by heat.
REFERENCES:
Juni, K, Masahiro Nalcano and Miho Kubota, Controlled Release of Aclarabicin, An Anticancer Antibiotic, From Poly-.beta.-hydroxybutyric Acid microspheres, J. Controlled Release, 4(25-32) 1986.
Lee de, L. G. J., le Boer, A. G. and E. Portzger Riste-Controlled Rectal Drug Delivery In man with A Hydrogel Preparation, J. Controlled Release, 4(17-24) 1986.
Kwong, A. K., S. Chou, A. M. Sun, M. V. Sefton and M. F. A. Goosen, In Vitro and In Vivo release of Insulin from Poly(Lactic Acid) Micro Beads and Pellets, J. Controlled Release 4(47-62) 1986.
Drobnik Jaroslav
Rypacek Frantisek
Uher Jan
Ceskoslovenska akademie ved
Friedman Stanley J.
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