Production of 2-alkoxy or aryl(lower)alkoxy-6-methoxy-1-naphthal

Details Production of 2-alkoxy or aryl(lower)alkoxy-6-methoxy-1-naphthal Production of 2-alkoxy or aryl(lower)alkoxy-6-methoxy-1-naphthal

1989-04-27

1990-04-03

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 41548

Patent

active

049142437

ABSTRACT:
Process for the production of 2-alkoxy or aryl(lower)alkoxy-6-methoxy-1-naphthalenecarboxaldehyde chemical intermediates by demethylating 2,6-dimethoxy-1-naphthalenecarboxaldehyde with a nucleophilic sulfide reagent at the 2-position and reacting the resulting phenolate salt with an alkylating reagent. Said aldehydes are themselves intermediates for the manufacture of compounds which inhibit aldose reductase and are useful for the treatment of diabetic complications.

REFERENCES:
patent: 4439617 (1984-03-01), Sestanj et al.
patent: 4568693 (1986-02-01), Sestanj et al.

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