Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1987-11-16
1990-04-03
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530321, C07K 764
Patent
active
049141880
ABSTRACT:
Novel cyclosporin analogs containing a MeAla or MeAbu residue at the 6-position of the cyclic undecapeptide have been synthesized and found unexpectedly to exhibit antagonistic activity toward cyclosporin A binding to its cytosolic protein receptor, cyclophilin, without being immunosuppressive.
REFERENCES:
patent: 4102877 (1978-07-01), Nutt
patent: 4108985 (1978-08-01), Ruegger et al.
patent: 4117118 (1978-09-01), Harri et al.
patent: 4210581 (1980-07-01), Ruegger et al.
patent: 4220641 (1980-09-01), Traber et al.
patent: 4288431 (1981-09-01), Traber et al.
patent: 4289851 (1981-09-01), Traber et al.
patent: 4384996 (1983-05-01), Bollinger et al.
patent: 4396542 (1983-08-01), Wenger
patent: 4639434 (1987-01-01), Wenger et al.
patent: 4681754 (1987-07-01), Siegl
patent: 4703033 (1987-10-01), Seebach
R. Wenger, Total Synthesis--Change in Molecular Structure--Biological Effect: Cyclosporin as Example, Sandorama, 1984/111, pp. 4-11.
H. Kobel and R. Traber, Directed Biosynthesis of Cyclosporins, European J. Appln. Microbiol Biotechnol., 14, 237-240 (1982).
Rudinger, Peptide Hormones, Parsons (ed.), U. Park Press, pp. 1-7 (1976).
Boger Joshua S.
Dumont Francis J.
Durette Philippe L.
Pessolano Arsenio A.
Sigal Nolan H.
Chan Christina
DiPrima Joseph F.
Lee Lester L.
Merck & Co. , Inc.
North Robert J.
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