Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1993-08-09
1994-10-25
Lone, Werren B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
568824, A61K 3107, A61K 3170
Patent
active
053589726
ABSTRACT:
This invention provides a purified retro-retinoid compound characterized by a molecular mass of about 302 daltons. Also provided by this invention is a method of enhancing the growth of a cell in a vitamin A reduced environment which comprises contacting the cell with an effective growth enhancing amount of a compound having a structure: ##STR1## wherein the configuration of the C6, C8, C10 and C12 double bond independently is Z or E and the absolute configuration at C-14 is independently R or S; wherein R.sub.1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acid halide, amide, nitrile, or amine; and wherein R.sub.2 is hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R.sub.1 and R.sub.2 are replaced by a 14, 15-oxirane group; and wherein the retro structure is alpha or gamma. Further provided are a method for enhancing transcription of a gone regulated by retinoid in a cell, or a method for enhancing an immune response in a subject.
REFERENCES:
patent: 4092366 (1978-05-01), Oroshnik
patent: 4829082 (1989-05-01), Shinkai et al.
patent: 5037655 (1991-08-01), Giovanoni
patent: 5051449 (1991-09-01), Kligman
patent: 5075340 (1991-12-01), Barua et al.
patent: 5190876 (1993-03-01), Merrill, Jr. et al.
patent: 5243094 (1993-08-01), Borg
Buck Jochen
Derguini Fadila
Hammerling Ulrich
Nakanishi Koji
Lone Werren B.
Sloan-Kettering Institute for Cancer Research
The Trustees of Columbia University in the City of New York
White John P.
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