Refrigeration – Low pressure cold trap process and apparatus
Patent
1987-09-29
1989-02-28
Bennet, Henry A.
Refrigeration
Low pressure cold trap process and apparatus
62275, 118 501, B01D 800
Patent
active
048074420
ABSTRACT:
A method and apparatus for ultrarapid cooling of tissue samples against a chilled cryogenic surface. The cryogenic surface is enclosed in a high vacuum chamber during cooling of the cryogenic surface. Dry non-condensable room temperature gas is introduced from an external source to raise the chamber pressure just prior to slamming or plunging a sample against the cryogenic surface. The cryogenic surface is heated for regeneration or cleaning purposes between each successive sample.
REFERENCES:
Polaron Instruments Inc., "The Slammer" (brochure).
Reichert-Jung, "Cryofract 190 Cryoblock" (brochure).
Reichert-Jung, "Cryovacublock"-Instruction Manual.
Escaig, Jacques, "Control of Different Parameters for Optimal Freezing Conditions", Science of Biological Specimen Preparation, pp. 117-122.
Handley, Dean A., et al, "The Design and Use of a Simple Device for Rapid Quench-Freezing of Biological Samples", Journal of Microscopy, Mar. 1981, at pp. 273-282.
Escaig, Jacques, "New Instruments Which Facilitate Rapid Freezing at 83K and 6K", Journal of Microscopy, Jun. 1982, at pp. 221-229.
Boyne, Alan F., "A Gentle, Bounce-Free Assembly for Quick-Freezing Tissues for Electron Microscopy: Application to Isolated Torpedine Ray Electrocyte Stacks", Journal of Neuroscience Methods, 1 (1979), pp. 353-364.
Coulter, H. David, "Freezing and Drying of Biological Tissues with a Toggle-Link Helium Freezer and an Improved Freeze-Drying Apparatus: Application to Neuropeptide Immunocytochemistry", Journal of Electron Microscopy Technique, (1986), at pp. 315-328.
Med-Vac Inc., "Cryopress" (brochure).
Quick Freezing Devices, "Quick Freezing by Bounce-Free Delivery" (brochure).
Moor, H. et al, "The Influence of High Pressure Freezing on Mammalian Nerve Tissue", Cell and Tissue Research, (1980), at pp. 201-216.
Linner John G.
Livesey Stephen A.
Bennet Henry A.
Board of Regents , The University of Texas System
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