Alpha factor leader sequence directed secretion of insulin

Details Alpha factor leader sequence directed secretion of insulin Alpha factor leader sequence directed secretion of insulin

1986-10-23

1990-04-03

Teskin, Robin

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 435255, 935 11, 935 47, 935 48, 935 49, 935 13, 935 28, 935 37, 935 69, 536 27, C12P 2100, C12P 2102, C12N 1500, C12N 500

Patent

active

049140264

ABSTRACT:
Methods and compositions are provided for efficient production of polypeptides having insulin activity. The proinsulin gene is joined to secretion and processing signals for expession and secretion in yeast. The product may be obtained in enhanced yield in the nutrient medium.
Cell line AB103(PYinsl) was deposited at the A.T.C.C. on Apr. 6, 1983 and given Accession No. 20,670.

REFERENCES:
patent: 4338397 (1982-07-01), Gilbert et al.
patent: 4431740 (1984-02-01), Bell et al.
patent: 4546082 (1985-10-01), Kurjan et al.
Bennetzen et al., J. Biol Chem. vol. 257(6) Mar.-25-82 "Codon Secretion in Yeast".
Hitzeman et al., Science vol. 219, pp. 620-625 Feb. 11, 1983 "Secretion of Human Interfemms by Yeast".

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