Endothelin antagonists incorporating a cyclobutane

Details Endothelin antagonists incorporating a cyclobutane Endothelin antagonists incorporating a cyclobutane

1993-09-29

1996-02-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514510, 514532, 514534, 514535, 514539, 514545, 514561, 514562, 514564, 514569, 514617, 514618, 514620, 514621, 514622, 514680, 514712, 514716, 514717, 514718, 514719, 514721, 514727, 514729, 514732, 560 10, 560 21, 560 23, 560 24, 560 25, 560 28, 560 52, 560 56, 560101, 560102, 564154, 564155, 564157, 564158, 564161, 564162, 564163, 564164, 564165, 564169, 564172, 568 31, 568 42, 568 43, 568 56, 568 58, 568306, 568326, 568585, 568586, 568632, 568633, 568634, 568659, 568660, 568661, 568662, 568705, 568808,

Patent

active

054929172

ABSTRACT:
Novel compounds of the general structural formula I: ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, inflammatory diseases including Raynaud's disease and asthma.

REFERENCES:
Chemical Abstracts, vol. 108, No. 21925, Uno et al., 1987 "Preparation of 1-[Clarlang-and Sulfamoyl)alkyl]-1,4-diazacycloalkene derivatives as CA antagonists".
Nature, vol. 365, pp. 759-761, 21 Oct. 1993, by Martine Clozel, et al.
Proc. Natl. Acad. Sci. USA, vol. 91, pp. 8052-8056, Aug. 1994, Pharmacology, by E. H. Ohlstein, et al.
The Journal of Pharmacology and Experimental Therapeutics, vol. 271, No. 2, pp. 755-761, 1994, by P. Nambi, et al.
The Journal of Pharmacology and Experimental Therapeutics, vol.271, No. 2, pp. 762-768, 1994, by E. H. Ohlstein, et al.
The Journal of Pharmacology and Experimental Therapeutics, vol. 271, No. 2, pp. 769-775, 1994, by D. P. Brooks, et al.
The Journal of Pharmacology and Experimental Therapeutics, vol. 270, pp. 228-235, 1994, by M. Clozel, et al.
Chemical Abstract, vol. 100 (15) No. 138,708z, Fujiwara et al., 1989, "Studies on synthesis of 10,11-dihydro-5H-debenzy(a,a)cycloheptene derivatives".
Chemical Abstract vol. 91 (3) No. 20181s, Bicherov et al., "Tiberzotrophyin salts" 1979.

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