Process for preparation of N.sup.7 -amidino substituted mitomyci

Details Process for preparation of N.sup.7 -amidino substituted mitomyci Process for preparation of N.sup.7 -amidino substituted mitomyci

1985-04-29

1987-03-24

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

540602, 540603, 544 582, 544142, 546199, C07D48704

Patent

active

046526447

ABSTRACT:
There is disclosed a process for the preparation of N.sup.7 -amidino substituted mitomycin C derivatives. The process comprises reacting mitomycin C or an N.sup.1a substituted derivative thereof such as porfiromycin with a chloroformimidinium salt in a polar solvent at low temperature. This reaction is conducted in the presence of a tertiary amine. This process eliminates the need for a strong base such as NaH prior to addition of a chloroformimidinium salt.

REFERENCES:
patent: 4327096 (1982-04-01), Marsili et al.
patent: 4567256 (1986-01-01), Vyas et al.

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