Prolonged release microcapsule and its production

Details Prolonged release microcapsule and its production Prolonged release microcapsule and its production

1984-11-01

1987-03-24

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

264 46, 424 85, 424DIG15, 4284022, 514 2, 514800, 514822, 514963, A61K 952, B01J 1302

Patent

active

046524410

ABSTRACT:
A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.

REFERENCES:
patent: 3523906 (1970-08-01), Vrancken et al.
patent: 3691090 (1972-09-01), Kitajima et al.
patent: 3773919 (1973-11-01), Boswell et al.
patent: 4234571 (1980-11-01), Nestor et al.
patent: 4272398 (1981-06-01), Jaffe
patent: 4273920 (1981-06-01), Nevin
The Pharmacopoeia of Japan, 10th Edition, 1981, English version, Society of Japanese Pharmacopoeia, Yakuji Nippo, Ltd., 1982, pp. 16-21.
Microcapsule, Industrial Technology Library 25, pp. 102-103 (1971).
Journal of the Chemical Society of Japan vol. 72, pp. 493-499 (1969).

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