Meso-azacyclic amides of imidazopyridine carboxylic acids and an

Details Meso-azacyclic amides of imidazopyridine carboxylic acids and an Meso-azacyclic amides of imidazopyridine carboxylic acids and an

1992-06-10

1993-03-23

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514413, C07D48704, A61K 3140

Patent

active

051965470

ABSTRACT:
The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT.sub.3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.

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Fludzinski et al., J. Med. Chem., Inazoles as Indole Bioesters, 30 No. 9, 1535-7, Apr. 19, 1987.

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