Certain indole compounds which inhibit EGF receptor tyrosine kin

Details Certain indole compounds which inhibit EGF receptor tyrosine kin Certain indole compounds which inhibit EGF receptor tyrosine kin

1991-04-16

1993-03-23

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546285, 546330, 548503, 548505, C07D20914, C07D20918, A61K 31405

Patent

active

051964465

ABSTRACT:
Heteroarylethenediyl compounds wherein the heteroaryl group can be mono- or icyclic heteroaryl and the aryl group can be or mono- or bicyclic carbocyclic, said compound optionally substituted or polysubstituted, with the proviso that the heteroaryl group is not furyl or thienyl when the ethenediyl group has geminal cyano substituents, and pharmaceutical compositions comprising said compounds, and the use thereof for inhibiting a protein tyrosine kinase portion of a receptor selected from epidermal growth factor and platelet derived growth factor in a patient suffering from such disorder.

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Chemical Abstracts, 107(19):17642h (1987).

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