Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1991-08-07
1992-09-08
Tsang, Cecilia
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544244, 544313, 544314, 544317, A61K 31505, C07D23902, C07D40504
Patent
active
051459604
ABSTRACT:
Antiviral activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1 is a pyrimidine base or an analog thereof and R.sub.2 and R.sub.3 are independently hydrogen, --PO.sub.3 H.sub.2 or ##STR2## wherein X.sub.7 is hydrogen, alkyl, substituted alkyl or aryl.
REFERENCES:
patent: 4788181 (1988-11-01), Driscoll et al.
patent: 4855466 (1989-08-01), Zahler et al.
patent: 4918075 (1990-04-01), Zahler et al.
patent: 5059690 (1991-10-01), Zahler et al.
Van Aerschot et al., "2'-Azido-2', 3'dideoxythymidine . . . " Antiviral Research, vol. 14, pp. 357-369 (1990).
Warshaw et al., "2'-Azido-2,3'-dideoxypyrimidine . . . " J. Med. Chem., vol. 33, pp. 1663-1666 (1990).
Shealy et al. . . . , "Carbocyclic Analogues of 5-Substituted Uracil . . . " J. Med. Chem., vol. 26, pp. 156-161 (1983).
Goodchild et al., "The Carbocyclic Analogue Of . . . ", Nucleosides & Nucleotides, 5(5), pp. 571-578 (1986).
Herdewijn et al., "Synthesis and Antiviral Activity . . . ", J. Med. Chem., vol. 28, No. 5, pp. 550-555 (1985).
Takano et al., "Entantio-controlled Route . . . ", J. Chem. Soc., Chem. Comm., 1988, pp. 189-191.
Ueda et al., "Chemical Conversions of nucleosides . . . ", Nucleic Acids Research Symposium #9, 1981, pp. 91-94.
Shuto et al., "Chemical Conversion Of Uridine . . . ", Nucleosides & Nucleotides, 1(3), pp. 263-273 (1982).
Rosenthal et al., "Branch-chain sugar nucleosides . . . ", Can. Jour. of Chem., vol. 47, pp. 4477-4481 (1969).
Action et al., "Improved Antitumor Effects . . . ", J. Med. Chem., 1979, vol. 22, No. 5, pp. 518-525.
Bamford et al., "Synthesis and Antiviral Activity of . . . ", J. Med. Chem., 1990, vol. 33, pp. 2494-2501.
Pudlo et al., "A New and Novel Approach . . . ", Tetrahedron Letters, vol. 31, No. 22, pp. 3101-3104, 1990.
DeClercq et al., "Targets for the Design of Antiviral Agents", pp. 203-230, 1983.
Huryn et al., "Synthesis of ISO-DDA . . . ", Tetrahedron Letters, vol. 30, No. 46, pp. 6259-6262 (1989).
Montgomery et al., "Isonucleosides.2.Purine and Pyrimidine . . . ", J. Org. Chem., vol. 43, No. 4, 541-44 (1978).
Shimada et al., "Oxetanocin, a Novel Nucleoside From Bacteria", Jour. of Antibiotics, vol. 39, No. 11, pp. 1623-1625 (1988).
Shimada et al., "Derivatives of Oxetanocin . . . ", Jour. of Antibiotics, vol. 40, No. 12, pp. 1788-1789 (1987).
Nishiyama et al., "Selective Inhibition of . . . ", Antimicrobial Agents Chemother., vol. 32, pp. 1053-1056 (1988).
Shimada et al., "Oxetanocins, Novel Nucleosides . . . ", Abst. #1008, 28th Interscience Conf. on Antimicorbial Agents & Chemotherapy, Oct. 1988.
Reist et al., "Branched Chain Sugars . . . ", J. American Chem. Soc., vol. 90, pp. 3852-3857 (1968).
Reist, "Andenine Nucleosides of Branched-Chain Sugars", Chemistry & Industry, Nov. 1967, pp. 1957-1958.
Montgomery et al., "Isonucleosides.1.Preparation of . . . ", J. Org. Chem., vol. 40, No. 13, pp. 1923-1927, (1975).
Montgomery et al., "Isonucleosides II.Purine and Pyrimidine . . . ", Abst. 64, Papers Am. Chem. Soc., vol. 173.
Imai et al., "synthesis Of Purine Nucleosides . . . ", Chem. Abst., vol. 66 (25), 115923h, 1967.
Slusarchyk et al., U.S. Ser. No. 322,375 filed Mar. 13, 1989.
Tino Joseph A.
Zahler Robert
Davis Stephen B.
E. R. Squibb & Sons Inc.
Tsang Cecilia
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