Degeneration-resistant solventogenic clostridia

Details Degeneration-resistant solventogenic clostridia Degeneration-resistant solventogenic clostridia

1992-01-21

1993-05-11

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435151, 435152, 435153, 435154, 435160, 435842, C12P 728, C12P 736, C12P 716, C12R 1142

Patent

active

052100324

ABSTRACT:
Butanol and acetone are major end products of a bacterial fermentation process carried out by anaerobic saccharolytic clostridia such as Clostridium acetobutylicum. However, these organisms degenerate upon repeated subculture of growing cells, thereby losing their capacity to produce solvents and to develop into spores. A novel class of degeneration-resistant mutants of C. acetobutylicum, generated by transposon insertion mutagenesis, has been produced employing a novel selection procedure. Upon subculture the mutant cells survive significantly longer than the parental cells without altered solventogenic characteristics. The mutant organism, the technique for its isolation and its use are provided.

REFERENCES:
patent: 4521516 (1985-06-01), Lemme et al.
patent: 4539293 (1985-09-01), Bergstrom
patent: 4560658 (1985-12-01), Datta et al.
patent: 4757010 (1988-07-01), Hermann et al.
patent: 5063156 (1991-11-01), Glassner et al.

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