Treatment of cancer with peptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 13, 514 16, 514 15, 530328, 530327, 530326, A61K 3800, C07K 500, C07K 700, C07K 1700

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active

057365172

ABSTRACT:
A method of treating cancer in a human patient, the method involving administering to the patient a cancer cell inhibiting amount of an analog of a naturally occurring biologically active peptide or a fragment thereof, the peptide being one of mammalian gastrin-releasing peptide, neuromedin B, neuromedin C, amphibian bombesin, or litorin.

REFERENCES:
patent: 4321260 (1982-03-01), Auclair
patent: 4473555 (1984-09-01), Nestor et al.
patent: 4569788 (1986-02-01), Mulshine et al.
patent: 4659695 (1987-04-01), Labrie
patent: 4743589 (1988-05-01), Labrie et al.
patent: 4745102 (1988-05-01), Labrie et al.
patent: 4775660 (1988-10-01), Labrie et al.
patent: 5217955 (1993-06-01), Bogden et al.
patent: 5244883 (1993-09-01), Cai et al.
patent: 5428019 (1995-06-01), Edwards et al.
Szepeshazi et al., Dec. 16, 1992, J. Nat'l Cancer Institute (United States), 84 (24) pp. 1915-1922.
Yano et al., Aug. 15, 1992, Cancer Res., vol. 52(16), pp. 4545-4547.
Milovanovic et al., 1992, Prostate vol. 20 (4) pp. 269-280.
Radulovic et al., Nov. 1, 1991, Cancer Res., vol. 51(21) pp. 6006-6009.
Narayan, et al., Feb. 1992, vol. 3 pp. 111-118.
Leban et al., Mar. 1993, Proc. Nat'l Acad. Sci., vol. 90, pp. 1922-1026.
Rivier et al., "Bombesin, Bombesin Analogues, and Related Peptides: Effects on Thermoregulation", 17:1767, 1978.
Cuttitta et al., "Autocrine growth factors in human small cell lung cancer", Cancer Surveys 4:708, 1985.
Zachary et al., "High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells," Proc. Natl. Acad. Sci. USA, 82:7616, Nov. 1985.
Heinz-Erian et al., "Bombesin analogues: a new class of bombesin receptor antagonists", pp. G439-G442, (1987).
Martinez et al., "Synthesis and Biological Activities of Some Pseudo-Peptide Analogues of Tetragastrin: The Importance of the Peptide Backbone", J. Med. Chem. 1985, 28:1874-1879.
Aumelas et al., ".sup.1 H and .sup.13 C n.m.r. studies of pseudo-peptide analogues of the C-terminal tetrapeptide of gastrin", Int. J. Peptide Protein Res., 1987, 30:596-604.
Dubreuil et al., "Degradation of a Tetragastrin Analogue by a Membrane Fraction from Rat Gastric Mucosa", Drug Design and Delivery, 1987, 2:49-54.
Gargosky et al., "C-Terminal bombesin sequence requirements for binding and effects on protein synthesis in Swiss 3T3 cells", Biochem. J., 1987, 247:427-432.
Heikkila et al., "Bombesin-related peptides Induce Calcium Mobilization in a Subset of Human Small Cell Lung Cancer Cell Lines", The Journal of Biological Chemistry, 1987, 262:16456-16480.
Alexander et al., "Effects of Bombesin on Growth of Human Small Cell Lung Carcinoma in Vivo", Cancer Research, 1988, 48:1439-1441.
Rossowski et al., "Effects of a Novel, Potent Bombesin Antagonist Analogue on Bombesin-Stimulated Gastric Gastric Acid Secretion and Growth Hormone Release in the Pentobarbital-Anesthetized Rat.," 1988 Abstract.
Leij et al. "Recombinant Interleukin-2 Stimulated Lymphocytes in Peripheral Blood as Effector Cells for of Cell Lysis in Small-Cell Lung Carcinoma," 1988, 132:1223.
Heimbrook et al., "Elucidation of a Novel Gastrin Releasing Peptide Antagonist", (to be published in: Synthetic Peptides: Approaches to Biological Problems, vol. 86. (1994).
Woll et al., "Bombesin is a Specific Receptor Antagonist in Swiss 3T3 Cells", Biochemical and Biophysical Research Communications, 1988, 155:359-365.
Caranikas et al., "Synthesis and Biological Activities of Substance P Antagonists", J. Med. Chem. 1982, 25:1313-1316.
Rosell et al., "Substance P-Antagonists: a new type of pharmacological tool", Trends in Pharmacological Sciences 1982, 3:211-212.
Lundberg et al., "A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig", Proc. Natl. Acad. Sci. USA 1983, 80:1120-1124.
Engberg et al., "A synthetic peptide as an antagonist of substance P", Nature 1981, 293:222-223.
Mizrahi et al., "Substance P Antagonists Active in vitro and in vivo", European Journal of Pharmacology, 1982:101-105.
Leander et al., "Aspecific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation", Nature 1981, 294:467-469.

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