Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1983-11-03
1986-10-28
Kight, John
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424 76, 424 65, 424 25, A61L 901, A61L 904
Patent
active
046198245
DESCRIPTION:
BRIEF SUMMARY
This invention relates to a process to prevent water desorption in a chemical liquid active substance carried on an absorbing support.
Various cases are known, in which one or more chemical substances are applied on to natural or synthetic substrates in particular for preservation and/or protection thereof from external aggressions of chemical, biological or other nature. There can be cited for example the protection of plants, stones, wood, leather, living organisms, body hygiene, and the like.
Many other cases are known, wherein one or more chemical substances are applied on to natural or synthetic substrates, in particular, for realizing an exchange with environment, the surrounding medium, or any other support. There can be cited for example the case of the progressive release of a perfume or an active substance, for deodorizing environments, desinfection of atmospheres, fight against insects.
In several applications, however, the substrates carrying the active substance is permanently, periodically or else, accidentally exposed to the action of water.
In many cases, such water provokes progressive, often rapid, desorption of the active principles in the substrate, thereby resulting in considerable loss of active substance and decrease with time of the efficiency of the system. To prevent or at least reduce any consequences of such phenomenon, processes or means substantially comprising hydrofugation and water proofing have been resorted to. Such means and processes may be classified into three main categories:
(1) Preliminary hydrofugation of the support before application of the active principle(s), the hydrofugating agent being applied directly or in solution in a solvent, or else, in emulsion in water.
(2) Application of the active principle(s) on to the substrate followed by hydrofugation, with the hydrofugating agent being applied directly or in solution in a solvent, or else, in emulsion in water.
(3) Incorporation of a hydrofugating agent into the active substance(s) as a solution or emulsion, then application of such composition onto the substrate.
Such processes, however, have major deficiencies in a great number of cases:
(1) Generally, in order to fight the consequences of water desorption in the active principles, it is necessary to incorporate large quantities of hydrofugating agent thereinto, hence limiting the quantities of active substance(s) to be carried by the substrate.
(2) The process for preliminary hydrofugation of the support through incorporation of the hydrofugating agent thereinto as a solution in a solvent or as an emulsion always requires an operation for removing the vehiculent, which can only be expensive, before application of the active principle(s). Moreover, when a water emulsion of the hydrofugating agent is resorted to, the emulsifier used generally remains on the substrate and provokes substantial reduction in the qualitative properties of the hydrofugation.
(3) When hydrofugation takes place after application of the active principle(s) onto the substrate, the same deficiencies as mentioned above are to be observed. Moreover, when the substrate is to carry volatile compositions, for the progressive evaporation thereof into the atmosphere, the required quantities of hydrofugating agent which must be used are such that in many cases they modify normal evaporation of such compositions unless they should totally stop it.
(4) Very often, the known hydrofugation processes do not stop or modify the water desorption phenomenon in the active principle(s) carried by the substrate.
(5) In many cases, the known hydrofugation processes are not applicable in particular when it is desired to treat substrates such as animal tissues, vegetal tissues, human tissues, or else, natural substrates or materials, of which the original conditions or aspect should not be modified.
The Applicant has now discovered fortuitously and surprisingly that it was possible to reduce to minimum water desorption in an active principle carried by a substrate by acting by means known in themselves upon
Delagneau Hubert
Weiss Richard
Kight John
Moore M. L.
Reckitt & Colman S.A.
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