Synthesis of hydroxamic acid derivatives

Details Synthesis of hydroxamic acid derivatives Synthesis of hydroxamic acid derivatives

1999-06-09

2000-07-25

Celsa, Bennett

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530331, 530334, 525 5411, 525374, 525377, 560312, C07K 104, C08G 6348

Patent

active

06093798&

ABSTRACT:
The present invention describes solid phase reaction products of a solid substrate carrying a plurality of covalently bound hydroxylamine or protected hydroxylamine groups of formula (A) or (B): ##STR1## where P.sub.1 is hydrogen or an amino protecting group, P.sub.2 is hydrogen or a hydroxyl protecting group, and the bond designated (a) covalently links the formula (A) or (B) to the residue of the solid substrate, and is cleavable under acid conditions or by photolysis. The solid phase reaction products can be used for the synthesis of hydroxamic acid derivatives or a combinatorial library of such compounds.

REFERENCES:
patent: 4461876 (1984-07-01), Lieberman
patent: 4868248 (1989-09-01), Sparapany
Chemical Abstracts, vol. 77, No. 24 (Dec. 11, 1972), Abstract No. 153114e, Chernyshev, "Maleic Anhydride Copolymer," p. 39, col. 2, and SU A 342 865 (Institute of Fine Chemical Technology, Moscow) Jun. 22, 1972.
Polymer Bulletin, vol. 32, No. 3, pp. 273-279 (1994) XP002003868, Taek Seung Lee, "Synthesis of Porous Poly(Hydroxamic Acid) from Poly(Ethyl Acrylate Co-Divinylbenzene)."

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