Synthesis of camptothecin and analogs thereof

Details Synthesis of camptothecin and analogs thereof Synthesis of camptothecin and analogs thereof

1987-03-31

1990-01-16

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 48, 546 92, A61K 3147, C07D491147, C07D49122

Patent

active

048944564

ABSTRACT:
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.

REFERENCES:
patent: 4473692 (1984-09-01), Miyasaka et al.
patent: 4545880 (1985-10-01), Miyasaka et al.
patent: 4604463 (1986-08-01), Miyasaka et al.
patent: 4778891 (1988-10-01), Tagawa et al.
Plattner et al., J. Am. Chem. Soc. 94(24), pp. 8613-8615 (1972).
Plattner et al., J. Org. Chem. 39(3), pp. 303-311 (1974).
Danishefsky et al., J. Org. Chem. 39(23), pp. 3430-3432 (1974).
Wani et al., J. Med. Chem. 23(5), pp. 554-560 (1980).
Wall et al., J. Med. Chem. 29(8), pp. 1553-1555 (08/86).
Wani et al., J. Med. Chem. 29(11), pp. 2358-2363 (11/86).
Govindachiari et al., Ind. J. Chem. 10(4), pp. 453-454 (1972).
Pan et al., Chemical Abstracts, vol. 84: 115629p (1976).

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