Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Patent
1997-06-20
2000-07-25
Nashed, Nashaat
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
530350, 702 19, 702 22, G01N 3348
Patent
active
060935731
ABSTRACT:
The present invention provides a crystallized Bactericidal Permeability-Increasing (BPI) protein; methods for x-ray diffraction analysis to provide x-ray diffraction patterns of sufficiently high resolution for three-dimensional structure determination of the protein, as well as methods for rational drug design, based on using amino acid sequence data and/or x-ray crystallography data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms; and atomic coordinates are provided yielding structural information on the lipid binding and lipid transport protein family that includes BPI, LBP, CETP and PLTP.
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Beamer Lesa J.
Carroll Stephen F.
Eisenberg David
Nashed Nashaat
The Regents of the University of California
XOMA
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