Human lysophospholipase

Details Human lysophospholipase Human lysophospholipase

1998-12-18

2000-07-25

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C12N 920

Patent

active

060935618

ABSTRACT:
The invention provides a human lysophospholipase (NHLP) and polynucleotides which identify and encode NHLP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of NHLP.

REFERENCES:
Sugimoto, H. et al., "Purification, cDNA Cloning, and Regulation of Lysophospholipase from Rat Liver", J. Biol. Chem., 271: 7705-7711 (1996).
Selle, H. et al., "Glycerophosphocholine release in human erythrocytes 1H spin-echo and .sup.31 p-NMR evidence for lysophospholipase", Eur. J. Biochem., 212: 411-416 (1993).
Enderesen, M.J. et al., "Increased lipolytic activity of sera from pre-eclamptic women due to the presence of a lysophospholipase", Scand. J. Clin. Lab Invest., 53: 733-739 (1993).
Anderson, R. et al., ".alpha.-Tocopherol Prevents Cyclosporin A-Mediated Activation of Phospholipase A.sub.2 and Inhibition of Na.sup.+, K.sup.+ -Adenosine Triphosphatase Activity in Cultured Hamster Renal Tubular Cells", Toxicol. Appl. Pharmacol., 125: 176-183 (1994).
Sugimoto, H. et al., (Direct Submission), GenBank Sequence Database (Accession D63885), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 1552243; GI 1552244), No Date Provided.
Sugimoto, H. and S. Yamashita, "Purification, Characterization, and Inhibition by Phosphatidic Acid of Lysophospholipase Transacylase from Rat Liver", J. Biol. Chem., 269: 6252-6258 (1994).
Wang, A. et al., (Direct Submission), GenBank Sequence Database (Accession U89352), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 1864158; GI 1864159), No Date Provided.
Wang, A. et al., "Cloning, Expression, and Catalytic Mechanism of Murine Lysophopholipase I", J. Biol. Chem. (May 9, 1997) 272 (19) : 12723-12729.

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