Protein inhibitors of phospholipase A.sub.2 purified from inflam

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4352402, 4353201, 530350, 530359, 530361, 536 231, 536 232, C12P 2106, C12N 500, C12N 1500, C07K 300

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053447646

ABSTRACT:
Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites which have an amino acid sequence given in FIGS. 3-1 through 3-3 or an amino acid sequence physiologically equivalent thereto, a process for preparation of said inhibitory protein wherein serum of mammalian animal is enzymatically treated, and a gene coding said inhibitory protein.

REFERENCES:
Davis, III et al., "Physiologic Inactivation of Fluid Phase C3b: Isolation and Structural Analysis of C3C C3d,g(.alpha.2D), and C3g", The Journal of Immunology, vol. 132, No. 4, Apr. 1984, pp. 1960-1966.
Proceedings of the National Academy of Sciences of USA, vol. 87, No. 7, pp. 2395-2399, Apr. 1990.
Pepinsky et al., "Five Distinct Calcium & Phospholipid Binding Proteins Share Homology with Lipocortin I*", The Journal of Biological Chemistry, vol. 263, No. 22, pp. 10799-10811 (Aug. 5, 1988).
Aarsman et al., "Lipocortin Inhibition of Extracellular and Intracellular Phospholipases A.sub.2 is Substrate Concentration Dependent", FEBS Letters, vol. 219, No. 1, pp. 176-180 (Jul. 1987).
Davidson et al., "Inhibition of Phospholipase A.sub.2 by Lipocortins and Calpactins", The Journal of Biological Chemistry, vol. 262, No. 4, pp. 1698-1705 (Feb. 5, 1987).
Suwa, Y., "Tanpakusitsu Kakusan Kouso", Proteins Nucleic Acids Enzymes, vol. 36, No. 3, pp. 333-341 (1991).
Misumi et al., "Nucleotide and Deduced Amino Acid Sequence of Rat Complement C3", Nucleic Acids Research, vol. 18, No. 8, p. 2178, Apr. 25, 1990.
Hellman, et al., "Amino Acid Sequence of the Trypsin-Generated C3d Fragment from Human Complement Factor C3", The Biochemical Journal, vol. 230, No. 2, pp. 353-361, Sep. 1, 1985.
Bruijn et al., "Human Complement Component C3: cDNA Coding Sequence and Derived Primary Structure", Proc. Natl. Acad. Sci. USA, vol. 82, pp. 708-712, Feb. 1985.
Pepinsky et al., (1986), JBC, vol. 261(9), pp. 4239-4246.

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