Methods of increasing sphincter competence

Details Methods of increasing sphincter competence Methods of increasing sphincter competence

1998-04-20

1999-11-16

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514324, 514428, A61K 3155, A61K 31445, A61K 3140

Patent

active

059858656

ABSTRACT:
A method of increasing gastroesophageal sphincter competence comprising administering to a human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt or solvate thereof.

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patent: 5567714 (1996-10-01), Bruns et al.
Isselbacher, et al., "Diseases of the Esophagus", Harrison's Principles of Internal Medicine, (9), 239, (1365-1367).
Harvey, "Gastric Antacids and Digestants" Goodman and Gilman's, The Pharmacologic Basis of Therapeutics, (6), 42, (988-995).
Timiras et al., "The Urinary System", Hormones and Aging, 8, (141-142).
Isselbacher, et al., "Dysuria, Incintinence, and Enuresis", Harrison's Principles of Internal Medicine, (9), 44, (222-223).

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