Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-09-12
1999-11-16
Ketter, James
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4352851, 424 34, 4242781, 604 46, A61K 4800, A61B 1720
Patent
active
059858478
ABSTRACT:
This invention relates to apparatus and compositions for administering antigens and immunostimulatory peptides to a mammalian host by the introduction of one or more naked polynucleotides to operatively encode for the antigens and immunostimulatory peptides, preferably by non-invasive means.
REFERENCES:
patent: 3969497 (1976-07-01), Kniker
patent: 5250293 (1993-10-01), Gleich
patent: 5262128 (1993-11-01), Leighton et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
Chien, "Mucosal Drug Delivery: Potential Routes for Noninvasive Systemic Administration," Novel Drug Delivery Systems, 50:197-228.
Chien, "Nasal Drug Delivery and Delivery Systems," Novel Drug Delivery Systems, 50:229-268.
Chien, "Transdermal Drug Delivery and Delivery Systems," Novel Drug Delivery Systems, 50:301-380.
Sloan, "Use of Solubility Parameters from Regular Solution Theory to Describe Partitioning-Driven Processes," Prodrugs Topical and Ocular Drug Delivery, 53:179-204.
Tice, et al., "Parenteral Drug Delivery: Injectables," Treatise on Controlled Drug Delivery, pp. 315-339, Marcel Dekker, New York.
Chang, et al., "Nasal Drug Delivery," Treatise on Controlled Drug Delivery, pp. 423-463, Marcel Dekker New York.
Been, et al., "One Binding Site Determines Sequence Specificity of Tetrahymena Pre-rRNA Self-Splicing, Trans-Splicing, and RNA Enzyme Activity," Cell, 47:207-216, Oct. 24, 1986.
Gillies, et al., "Expression of Human Anti-Tetanus Toxoid Antibody in Transfected Murine Myeloma Cells," Bio/Technology, 7:799-804, Aug. 1989.
Ward, et al., "Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli," Nature, 341:544-546, Oct. 12, 1989.
Wolff, et al., "Conditions Affecting Direct Gene Transfer into Rodent Muscle In Vivo," BioTechniques, 11:474-485 (1991).
Cohen, "Naked DNA Points Way to Vaccines," Science, 259:1691-1692, Mar. 19, 1993.
Acsadi, et al., "Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs," Nature, 352:815-818, Aug. 29, 1991.
Wolff, et al., "Direct Gene Transfer into Mouse Muscle in Vivo," Science, pp. 1465-1468, Mar. 1990.
Barr, et al., "Systemic Delivery of Recombinant Proteins by Genetically Modified Myoblasts," Science, 254:1507-1512, Dec. 1991.
Ulmer, et al., "Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein," Science, 259:1745-1748, Mar. 19, 1993.
"The Ultimate Delivery System: Lectro Patch Offers Large Molecule, 8 Day Drug Delivery," General Medical Company (1991).
Kaplan, et al., "Rational Immunotherapy with Interleukin 2," Bio/Technology, 10:157-162, Feb. 1992.
Caligiuri, et al., "Selective Modulation of Human Natural Killer Cells In Vivo After Prolonged Infusion of Low Dose Recombinant Interleukin 2," J. Clin. Invest., 91:123-132, Jan. 1993.
Teppler, et al., "Prolonged Immunostimulatory Effect of Low-Dose Polyethylene Glycol Interleukin 2 in Patients with Human Immunodeficiency Virus Type 1 Infection," J. Exp. Med., 177:483-492, Feb. 1993.
Stribling, et al., "Aerosol gene delivery in vivo," Proc. Natl. Acad. Sci. USA, 89:11277-11281, Dec. 1992.
Hefeneider, et al., "In Vivo Interleukin 2 Administration Augments the Generation of Alloreactive Cytolytic T Lymphocytes and Resident Natural Killer Cells," The Journal of Immunology, 130:222-227, Jan. 1983.
Goldstein, et al., Repetitive Weekly Cycles of Interleukin 2: Effect of Outpatient Treatment with a Lower Dose of Interleukin 2 . . . , Cancer Research, 49:6832-6839, Dec. 1, 1989.
Robinson, et al., "Use of Direct DNA Inoculations to Elicit Protective Immune Responses," Journal of Cellular Biochemistry, Supplement 17D, pp. 85 and 92, Mar. 1993.
Donohue, et al., "In Vivo Administration of Purified Jurkat-derived Interleukin 2 in Mice," Cancer Research, 44:1380-1386, Apr. 1984.
Lotz et al., ".beta. Cell Stimulating Factor 2/Interleukin 6 is a Costimulant for Human Thymocytes . . . " J. Exp. Med., 167:1253-1258, Mar. 1988.
Del Rey, et al., "Antidiabetic effects of interleukin 1," Proc. Natl. Acad. Sci. USA, 86:5943-5947, Aug. 1989.
Shields, et al., "Calorie restriction suppresses subgenomic mink cytapathic focus-forming murine leukemia virus transcription . . . " Proc. Natl. Acad. Sci. USA, 88:11138-11142, Dec. 1991.
Tang, et al., "Genetic immunization is a simple method for eliciting an immune response," Nature, 356:152-154, Mar. 12, 1992.
Krieg, et al., "Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs," Nucleic Acids Research, 12:7057-7071, 1984.
Gorman, et al., "The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells . . . " Proc. Natl. Acad. Sci. USA, 79:6777-6781, Nov. 1982.
Norton, et al., "Bacterial .beta.-Galactosidase as a marker of Rous Sarcoma Virus Gene Expression and Replication," Molecular and Cellular Biology, 5:281-290, Feb. 1985.
Davis, et al., "Direct Gene Transfer into Skeletal Muscle In Vivo: Factors Affecting Efficiency of Transfer and Stability of Expression," Human Gene Therapy, 4:151-159 (1993).
Davis, et al., "Plasmid DNA Is Superior to Viral Vectors for Direct Gene Transfer into Adult Mouse Skeletal Muscle," Human Gene Therapy, 4:733-740 (1994).
Carson Dennis A.
Raz Eyal
Ketter James
Taylor Stacy L.
The Regents of the University of California
LandOfFree
Devices for administration of naked polynucleotides which encode does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Devices for administration of naked polynucleotides which encode, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Devices for administration of naked polynucleotides which encode will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1324835