Methods of using hepatic-directed compounds in pretargeting stra

Details Methods of using hepatic-directed compounds in pretargeting stra Methods of using hepatic-directed compounds in pretargeting stra

1997-03-03

1999-11-16

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 24, 514 42, 514 54, A61K 3170, A61K 31715, A61K 3173, A61K 3814

Patent

active

059858265

ABSTRACT:
Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are disclosed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic mechanisms encountered by compounds which are not so directed. Hepatic-directed compounds useful in the methods disclosed include a hexose cluster characterized by multiple hexose residues connected in an iteratively branched configuration. In one embodiment, the hexose cluster comprises at least four hexose residues with each branch of the configuration having two prongs. In another embodiment, the hexose cluster comprises at least nine hexose residues with each branch of the configuration having three prongs.

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