Enhancement of antimicrobial peptide activity by metal ions

Details Enhancement of antimicrobial peptide activity by metal ions Enhancement of antimicrobial peptide activity by metal ions

1997-08-15

2000-03-28

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Phosphorus or phosphorus compound

424618, 424630, 424632, 424633, 424634, 424635, 424637, 424638, 424639, 424649, 424657, 424682, 514 2, 514 12, 514 21, A61K 3322, A61K 3334, A61K 3338, A61K 3802

Patent

active

060428481

ABSTRACT:
Provided are methods for maintaining or enhancing the antimicrobial activity of antimicrobial peptides, lytic peptides, and peptide-derived antibiotics by the use of metal ions. Also provided are pharmaceutical and other compositions comprising such peptides and/or at least one metal ion. Also provided are therapeutic and other methods for controlling the growth of undesirable or pathogenic microorganisms in various loci or milieu in, on, or outside the body employing these peptides and metal ions. Also provided are kits comprising containers containing a peptide and a metal ion(s), respectively.

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