Interferon polymer conjugates

Details Interferon polymer conjugates Interferon polymer conjugates

1999-04-06

2000-03-28

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

530351, 530409, 530410, 530411, A61K 3821, C07K 1113, C07K 1456

Patent

active

060428228

ABSTRACT:
Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a histidine. Also disclosed is a process for preparing the conjugates. The process includes contacting an alpha interferon with a succinimidyl carbonate-activated substantially non-antigenic polymer at a pH which is sufficient to facilitate covalent attachment of the polymer on a histidine of the alpha interferon.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4275000 (1981-06-01), Ross
patent: 4609546 (1986-09-01), Hiratani
patent: 4680338 (1987-07-01), Sundoro
patent: 4766106 (1988-08-01), Katre et al.
patent: 4810638 (1989-03-01), Albarella et al.
patent: 4894226 (1990-01-01), Aldwin et al.
patent: 4897471 (1990-01-01), Stabinsky
patent: 4904582 (1990-02-01), Tullis
patent: 4917888 (1990-04-01), Katre et al.
patent: 4935465 (1990-06-01), Garman
patent: 5004605 (1991-04-01), Hershenson et al.
patent: 5109120 (1992-04-01), Ueno et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5281698 (1994-01-01), Niteeki
patent: 5283317 (1994-02-01), Saifer et al.
patent: 5382657 (1995-01-01), Karasiewicz et al.
patent: 5468478 (1995-11-01), Saifer et al.
patent: 5539063 (1996-07-01), Hakimi et al.
patent: 5559213 (1996-09-01), Hakimi et al
patent: 5646242 (1997-07-01), Baker et al.
patent: 5650234 (1997-07-01), Dolence et al.
patent: 5676942 (1997-10-01), Testa
patent: 5711944 (1998-01-01), Gilbert et al.
patent: 5738846 (1998-04-01), Greenwald et al.
patent: 5747646 (1998-05-01), Hakimi et al.
patent: 5762923 (1998-06-01), Gross et al.
patent: 5951974 (1999-09-01), Gilbert et al.
patent: 5981709 (1999-11-01), Greenwald et al.
patent: 5985263 (1999-11-01), Lee et al.
Borukhov et al. Chemical Modification of the Recombinant . . . Biochem. Biophys. Res. Comm. vol. 167, No. 1, pp. 74-80, Feb. 28, 1990.
Zalipsky, et al., Attachment of Drugs to Polyethylene Glycols. Eur. Polym. J., vol. 19, No. 12, pp. 1177-1183 (1983).
Goeddel, D.V. et al., The Structure of Eight Distinct Coloned Human Leukocyte Interferon cDNAs, Nature vol. 290; pp. 20-26; Mar. 5, 1981.
Zalipsky S. et al., Evaluation of a New Reagent for Covalent Attachment of Polyethylene Glycol to Proteins, Biotechnology and Applied Biochemistry, vol. 15; pp. 100-114; 1992.
Kontsek, P., Human Type I Interferons: Structure and Function, Acta Virologica, vol. 38; pp. 345-360; 1994.
Kinstler, O.B. et al., Characterization and Stability of N-terminally PEGYlated rhG-CSF, Pharmaceutical Res., vol. 13, No. 7; pp. 996-1002; 1996.
Monkarsh, S.P. et al., Positional Isomers of Monopegylated Interferon alpha-2a: Isolation, Characterization, and Biological Activity, Analytical Biochemistry, vol. 247; pp. 434-440; 1997.
Viscomi, G.C., Structure-activity of Type I Interferons, Biotherapy, vol. 10; pp. 59-86; 1997.
Gotoh, Y., et al. Chemical Modification of Silk Fibroin with Cyanuric Chloride-Activated Poly(ethylene glycol): Analysis of Reaction by H-NMR Spectroscop and . . . , Bioconjugate Chem, vol. 4; pp. 554-559; 1993.
Lundblad, R.L., et al. Chemical Reagents for Protein Modification, CRC Press, Inc., vol. 1; pp. 105-125; 1988.
Shearwater Polymers, Inc. Catalog, p. 45; Jan. 1996.

Affiliated with

Also associated with

Rating

Interferon polymer conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Interferon polymer conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interferon polymer conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1323626