Process for the isolation of clavulanic acid and of pharmaceutic

Details Process for the isolation of clavulanic acid and of pharmaceutic Process for the isolation of clavulanic acid and of pharmaceutic

1998-07-10

1999-11-16

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435118, 435120, 435886, 435 41, 435 713, 540349, C12P 1714, C12P 1716

Patent

active

059856254

ABSTRACT:
A process for the isolation of clavulanic acid pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microogranism comprises the microfiltration of the broth without prior treatment.

REFERENCES:
patent: 3873425 (1975-03-01), Kobayashi et al.
patent: 4140764 (1979-02-01), Howarth
patent: 4148880 (1979-04-01), Celmer et al.
patent: 4427690 (1984-01-01), Cole et al.
patent: 4886602 (1989-12-01), Kuehne et al.
patent: 4956180 (1990-09-01), Cassani et al.
patent: 5268283 (1993-12-01), Mothes et al.
patent: 5310898 (1994-05-01), Copar
patent: 5422256 (1995-06-01), Cooper et al.
Derwent WPI, Week 8109, Accession No. 81-14362D (Derwent abstract of Japanese Patent Kokai No. 55-162,993, Dec. 19, 1980).
Ullmann's Encyclopedia of Industrial Chemistry, VCH Publishers, New York, NY, 1990, vol. A16, pp. 194-195.
A.M.A. Nabais et al., "Ultrafiltration of fermented broths and solvent extraction of antibiotics", Bioprocess Engineering, 13, 215-221 (1995).
Schweitzer, Handbook of Separations for Chemical Engineers, 2nd edition, McGraw-Hill, New York, 1988, Section 2.1 "Membrane Filtrattion", pp. 2.1-2.103.
Belter et al., Bioseparations: Downstream Processing for Biotechnology, John Wiley & Sons, New York, 1988, pp. 1-17, 39-75, 237-255.
Noble and Stern, Membrane Separations Technology: Principles and Applications, Elsevier, Amsterdam, 1995, Chapter 8, pp. 353-413.
Mackay and Salusbury, "Choosing between centrifugal and crossflow microfiltration", The Chemical Engineer, Apr. 1988, pp. 45-50.
Michaels and Matson, "Membranes in biotechnology: state of the art", Desalination, v.53 (1985), 231-258.

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