Process for preparing 2-amino-1,3-alkanediol or derivative there

Details Process for preparing 2-amino-1,3-alkanediol or derivative there Process for preparing 2-amino-1,3-alkanediol or derivative there

1996-08-13

1999-07-20

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

562553, C07C20900

Patent

active

059257920

ABSTRACT:
A process for preparing an optically active dihydrosphingosine derivative is disclosed, comprising reducing a (2R,3R)-2-amino-3-hydroxyalkanoic acid derivative represented by formula (III): ##STR1## wherein R.sup.3 represents a straight-chain alkyl group having 7 to 21 carbon atoms; and R.sup.4 represents an amino group protecting group, (e.g., (2R,3R)-2-benzylamino-3-hydroxyoctadecanoic acid) with sodium tetrahydroborate in the presence of an acid. The process makes it feasible to produce an optically active dihydrosphingosine at high optical purity and through a simple process that is safe and easy to industrialize.

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