Process for preparing pyridinecarboxylic esters

Details Process for preparing pyridinecarboxylic esters Process for preparing pyridinecarboxylic esters

1997-07-15

1999-07-20

Fan, Jane

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21330

Patent

active

059257652

ABSTRACT:
A process for preparing pyridinecarboxylic esters of the general formula: ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1 -C.sub.6 -alkyl group, a C.sub.1 -C.sub.4 -alkoxycarbonyl group or a C.sub.1 -C.sub.4 -alkoxymethyl group, R.sup.2 is a C.sub.1 -C.sub.4 -alkyl group and X is chlorine or bromine. The pyridinecarboxylic esters are obtained by reacting the corresponding 2,3-dihalopyridines with carbon monoxide and a C.sub.1 -C.sub.4 -alkanol in the presence of a weak base and a complex of palladium with a bis(diphenylphosphine). Pyridinecarboxylic esters are intermediates for preparing herbicides and drugs against fibrotic diseases.

REFERENCES:
patent: 4128554 (1978-12-01), Heek
patent: 4254125 (1981-03-01), Sunder et al.
patent: 4618366 (1986-10-01), Cramp et al.
patent: 4995902 (1991-02-01), Brunner et al.
patent: 5142057 (1992-08-01), Suto et al.
patent: 5159113 (1992-10-01), Nicholas
patent: 5166352 (1992-11-01), Allphin
patent: 5288866 (1994-02-01), Strong
patent: 5294597 (1994-03-01), Foster et al.
patent: 5296601 (1994-03-01), Suto et al.
patent: 5334724 (1994-08-01), Kaufman et al.
patent: 5380861 (1995-01-01), Scalone et al.
patent: 5583241 (1996-12-01), Spindler
patent: 5614636 (1997-03-01), Roduit et al.
patent: 5676267 (1997-10-01), Slat et al.
Journal of Orgnaometallic Chemistry, (1995), 503, 143-148.
Inorganica Chimica Acta, (1994), 222, 213-224.
Journal of Heterocyclic Chemistry, (1990), 27, 243.
Chemical Abstracts, (1996), vol. 125, No. 3, 333323k.
Journal of American Chemistry Society, (1989), 111, 8742-8744.
Journal of Organometallic Chemistry, (1980), 45, 4680-4682.
Chemical Abstracts, (1994), vol. 122, 187621.
Chemical Abstracts, (1988), vol. 109, 68849.
Chemical Abstracts, (1969), vol. 73, 130894.
Shokubai Catalysis Society of Japan, 36 (1994).
Encyclopedia of Reagents for Organic Synthesis vol. 4,ed. L.A. Paquette, Johm Wiley & Sons Chichester, (1995), 2769-2771.
Shokubai, Catalysis Society of Japan, 36, (1994), 580-584 (translation),.
J. Mol. Cat. 66, (1991), 277.
Advance Organic Chemistry by March McGraw-Hill Book Co., 1968.

Affiliated with

Also associated with

Rating

Process for preparing pyridinecarboxylic esters does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing pyridinecarboxylic esters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing pyridinecarboxylic esters will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1322963