Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-01-16
1999-03-09
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530352, 435 691, 4352523, 4353201, 536 237, 935 11, 935 29, 935 72, C07H 100, C12N 1531, C12N 1575
Patent
active
058802622
ABSTRACT:
The invention provides Response Regulator polypeptides and DNA (RNA) encoding Response Regulator polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response Regulator polypeptides to screen for antibacterial compounds.
REFERENCES:
patent: 5606022 (1997-02-01), Rasmussen
patent: 5670350 (1997-09-01), Gaffney et al.
patent: 5686282 (1997-11-01), Gaffney et al.
patent: 5747286 (1998-05-01), Wallis
patent: 5766878 (1998-06-01), Wallis
patent: 5773250 (1998-06-01), Wallis
Accession No. P13800, SwissProt Database, World Wide Web server address: Amos Bairoch Medical Biochemistry Department Centre, Medical Universitaire 1, Rue Michele Servet, 1211 Geneva VI, Switzerland, 1994.
Andersson, et al., Gene, vol. 175, "Complementation of divergent mga genes in Group A Streptococcus", pp. 77-81, 1996.
Caparon, M. G., Journal of Bacteriology, vol. 174, "Environmental regulation of virulence in Group A streptococci: Transcription of the gene encoding M protein is stimulated by carbon dioxide", pp. 5693-5701, 1992.
Cheng, Q., et al., Molecular Microbiology, vol. 23, "The com locus controls genetic transformation in Streptococcus pneumoniae", pp. 683-692, 1997.
Dahl, M. K., et al., Journal of Biological Chemistry, vol. 267, "The phosphorylation state of the DegU response regulator acts as a molecular switch allowing either degradative enzyme synthesis of expression of genetic competence of Bacillus subtilis", pp. 14509-14514, 1992.
Feher, V. A., et al., Protein Science, vol. 4, "1H, 15N and 13C backbone chemical shift assignments, secondary structure, and magnesium-binding characteristics of the Bacillus subtilis response, etc.", pp. 1801-1814, 1995.
Fisher, S. L., et al., Biochemistry, vol. 35, "Kinetic comparison of the specificity of the vancomycin resistance kinase VanS for two response regulators, VanR and PhoB", pp. 4732-4740, 1996.
Guenzi, E., et al., Molecular Mirobiology, vol. 112, "A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae", pp. 505-515, 1994.
Havarstein, L. S., et al., Molecular Microbiology, vol. 21, "Identification of the streptococcal competence-pheromone receptor", pp. 863-869, 1996.
Henner, D. J., et al., Journal of Bacteriology, vol. 170, "Localization of Bacillus subtilis sacU(Hy) mutations to two linked genes with similarities to the conserved procaryotic family of two-component signaling systems", pp. 5102-5109, 1988.
Kaneko, T., et al., DNA Research, vol. 3, "Sequence analysis of the genome of the unicellular cyanobacterium Synechocytis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions", pp. 109-136, 1996.
Kleerebezem, M., et al., Molecular Microbiology, vol. 24, "Quorum sensing by peptide pheromones and two-component signal transduction systems in Gram-postive bacteria", pp. 895-904, 1997.
Kunst, F., et al., Research in Microbiology, vol. 145, "The DegS/DegU and ComP/ComA two-component systems are part of a network controlling degradative enzyme synthesis and competence in Bacillus subtilis", pp. 393-402, 1994.
Louw, M. E., et al., Applied Microbiology and Biotechnology, vol. 42, "Cloning and sequencing of the degS-degU operon from an alkalophilic Bacillus brevis", pp. 78-84, 1994.
Matsumura, P., et al., Journal of Bacteriology, vol. 160, "Overexpression and sequence of the Escherichia coli cheY gene and biochemical properties of the CheY protein", pp. 36-41, 1984.
Ogasawara, N., et al., DNA Research, vol. 1, "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin", pp. 1-14, 1994.
Ogura, K., et al., FEBS Letters, vol. 397, "Bacillus subtilis DegU acts as a postive regulator for comK expression", pp. 173-176, 1996.
Pestova, E. V., et al., Molecular Microbiology, vol. 21, "Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromoine and a two-component regulatory system", pp. 853-862, 1996.
Tanaka, T., et al., Journal of Bacteriology, vol. 170, "Cloning and characterization of Bacillus subtilis iep, which has postive and negative effects on production of extracellular proteases", pp. 3593-3600, 1988.
Volkman, B. F., et al., Biochemistry, vol. 34, "Three dimensional solution structure of the N-terminal receiver domain of NTRC", pp. 1412-1424, 1995.
Volz, K., Biochemistry, vol. 32, "Structural conservation in the CheY superfamily", pp. 11741-11753, 1993.
Weaver, K. E., et al., Journal of Bacteriology, vol. 170, "Regulation of the pAD1 sex pheromone response in Enterococcus faecalis: Construction and characterization of the IacZ transcriptional fusions in a key control region of the plasmid", pp. 4343-4352, 1988.
Gimmi Edward R.
King William T.
Moore William W.
SmitheKline Beecham p.l.c.
SmithKline Beecham Corporation
LandOfFree
Compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1322439