Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-07-29
1999-07-20
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142328, 514255, 544126, 544361, 546 93, A61K 3144, C07D40104
Patent
active
059256486
ABSTRACT:
Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions of formula (1.0) ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein a, b, c, d, R.sup.1 -R.sup.8, X and Z are defined herein. Such compounds are inhibitors of the enzyme, farnesyl protein transferase. The compounds are useful for inhibiting Ras function and therefore inhibiting the abnormal growth of cells, in a mammals such as a human.
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Cecil Textbook of Medicine, edited by Wyngaarden, J.B. et al., 19th edition, W.B. Saunders Co., pp. 827-831 and 2304-2305, 1992.
Cooper Alan B.
Desai Jagdish A.
Doll Ronald J.
Girijavallabhan Viyyoor M.
Lovey Raymond G.
Gupta Yogendra N.
Majka Joseph T.
Schering Corporation
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