High molecular weight polymer-based prodrugs

Details High molecular weight polymer-based prodrugs High molecular weight polymer-based prodrugs

1995-09-29

1999-03-09

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514283, 514449, 546 48, 546 51, 549510, 549511, A61K 3144, A61K 31335, C07D49122, C07D30514

Patent

active

058801316

ABSTRACT:
High molecular weight, water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active moiety;

REFERENCES:
patent: 4101380 (1978-07-01), Rubinstein et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4275000 (1981-06-01), Ross
patent: 4534899 (1985-08-01), Sears
patent: 4582805 (1986-04-01), Bozzelli et al.
patent: 4680338 (1987-07-01), Sundoro
patent: 4814470 (1989-03-01), Colin et al.
patent: 4904582 (1990-02-01), Tullis
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5015744 (1991-05-01), Holton
patent: 5019504 (1991-05-01), Christen et al.
patent: 5059699 (1991-10-01), Kingston et al.
patent: 5091176 (1992-02-01), Braatz et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5136060 (1992-08-01), Holton
patent: 5157049 (1992-10-01), Haugwitz et al.
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5489589 (1996-02-01), Wittman et al.
patent: 5498729 (1996-03-01), Domb
Bioconjugate Chemistry Sep./Oct. 1992 vol. 3, No. 5; 351-362, Maeda, Hiroshi et al.
Journal of Bioactive and Compatible Polymers vol. 10 Jan. 1995, 51-66; Ohya, Yuichi et al.
Polymer Bulliten 18, 487-493 (1987) Gehrardt et al.
J. of Controlled Release 10, (1989) 145-154 Veronese, F et al.
Cancer Chemother Pharmacol (1992) 31 255-257 Waud, W. et al.
Biotechnology and Applied Biochemistry 9, 258-268 (1987) Buckn, A. et al.
"Novel, Water-Soluble Phosphate Derivatives of 2'-Ethoxycarbonyl Paclitaxel . . . ", Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 3, pp. 247-252 (1995).
"Synthesis and Antitumor Evaluation of 2'-Oxycarbonyl Paclitaxel" Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 15, pp. 1861-1864 (1994).
Bonina, F.P. et al., "In vitro and in vivo evaluation of polyoxyethylene indomethacin esters as dermal prodrugs", Journal of Controlled Release 34 (1995) 223-232.
Devineni, D. et al., "Preparation and in Vitro Evaluation of Magnetic Microspere-Methotrexate Conjugate Drug Delivery Systems", Bioconjugate Chem. 6 (1995) 203-210.
Nichifor, M. et al., "Macromolecular Prodrugs of 5-Fluoroouracil. 1: Synthesis and Hydrolytic Stability", Journal of Bioactive and Compatible Polymers, vol. 10 (Jul. 1995) 199-222.
Senter, P.D. et al., "Poly(ethylene glycol)-Doxorubicin Conjugates Containing .beta.-Lactamase-Sensitive Linkers" Bioconjugate Chem. 6 (1995) 389-394.
Duncan, R. And F. Spreafico, "Polymer Conjugates: Pharmacokinetic Considerations for Design and Development" Clin. Pharmacokinet 27(4) (1994), 290-306.
Duncan, R., "Drug-polymer conjugates: potential for improved chemotherapy" Anti-Cancer Drugs 3 (1992) 175-210.
Maeda, H., "SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy" Advanced Drug Delivery Reviews, 6(1991) 181-202.
Poiani, G.J., "Conjugates of cis-4-Hydroxy-L-proline and Poly(PEG-Lys), a Water Soluble Poly(ether urethane): Synthesis . . . in Vivo" Bioconjugate Chem. 5 (1994), 621-630.
Traber, M.G. et al., "Efficacy of water-soluble vitamin E in the treatment of vitamin E malabsorption in short-bowel syndrome" Am. J. Clin Nutr. 59 (1994), 1270-1274.
Nathan, A. et al., "Strategies for Covalent Attachment of Doxorubicin to Poly(PEG-Lys), a New Water-Soluble Poly(ether urethane)" Journal of Bioctive and Compatible Polymers, vol. 9, (1994), 239-251.
Inada, Y. et al., "Biomedical and biotechnological applications of PEG--and PM-modified proteins" Tibtech, 13 (1995), 86-91.
Weissleder, R., "Quantitation of Slow Drug Release from an Implantable and Degradable Gentamicin Conjugate In Vivo . . . Imaging" Antimicrobial Agents and Chemotherapy, 39 (1995), 839-845.
Ranucci, E. et al., "Pharmacokinetic results on naproxen prodrugs based on poly(ethyleneglycols)s", J. Biomater, Sci. Polymer Edn., 6 (1994), 141-147.
Commercon et al, Tetrahedron Letters, vol. 33, No. 36, pp. 5158-5188 (1992).
Magre et al, J. Org. Chem., vol. 51, pp. 797-802 (1986).
Gueritte-Voegelein et al, J. Med. Chem., 34, pp. 992-998 (1991).
Zalipsky et al, Eur. Polym. J., vol. 19, No. 12, pp. 1177-1183 (1983).
Ouchi et al, Drug Design & Discovery, vol. 9, pp. 93-105, (1992).
Mathew et al, J. Med. Chem., 35, pp. 145-151 (1992).
Cecchi et al, J. Med. Chem., vol. 24, pp. 622-625 (1981).
Weiner et al, Journal of Medicinal Chemistry, vol. 16, No. 5, (1973).
Nicolaou, Nature, vol. 364, pp. 464-466, 29 Jul. 1993.
Nathan et al, "Polymers Preprints", 31, 1990, pp. 213-214.

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