Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1995-08-24
1999-07-20
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424464, 514886, 514863, 514944, 514937, 514962, 514969, 514679, A61K 920, A61K 906
Patent
active
059253762
ABSTRACT:
An improved method of treating psoriasis involves controlling the enhanced proliferation and terminal differentiation of psoriatic epidermis through the activity of epidermal phosphorylase kinase. In general, the method involves contacting psoriatic epidermal cells with a combination of substances affecting the activity of phosphorylase kinase. The combination can be: (1) a calmodulin inhibitor together with a stimulator of cAMP-dependent protein kinase II, (2) a calmodulin inhibitor together with a calcium channel blocker; (3) a stimulator of cAMP-dependent protein kinase II together with a calcium channel blocker; or (4) a calmodulin inhibitor together with a calcium channel blocker and a stimulator of cAMP-dependent protein kinase II. Alternatively, a selective phosphorylase kinase inhibitor such as curcumin can be administered, alone or with an agent such as vitamin D.sub.3 or an analogue thereof, etretinate, diltiazem, or anthralin. The invention also includes pharmaceutical compositions.
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