Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-11-04
1996-09-10
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4353201, 4351723, 435 697, 435948, 536 231, 935 27, 935 32, 935 57, 935 71, C12N 500, C12N 1500
Patent
active
055545289
ABSTRACT:
All lines of mammalian origin which have been stably transformed with a chimeric toxin gene expressed under the regulatory control of HIV cis-acting sequences and HIV trans-acting factors are provided by the present invention. HIV infection of a cell of such a transformed cell line results in the death of that cell due to the specific induction of toxin gene expression within the cell. As specifically exemplified, the toxin gene is the diphtheria toxin fragment A gene or a tox176 fragment A chain gene. Also provided by the present invention are recombinant nucleic acid molecules suitable for the stable transformation of a mammalian cell line to produce a transformed cell which will effectively commit suicide in response to HIV infection due to induction of toxin gene expression.
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Curiel Tyler J.
Harrison Gail M.
Maxwell Francoise
Maxwell Ian H.
Board of Revents of University of Colorado
Chambers Jasemine C.
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