Method for screening for alzheimer's disease

Details Method for screening for alzheimer's disease Method for screening for alzheimer's disease

1995-05-03

1999-03-09

Myers, Carla J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4351723, 4353201, 436 63, 536 2431, 536235, 935 9, 935 11, 935 23, 935 77, 935 78, C12Q 168, C12N 1511, C07H 2104

Patent

active

058798838

ABSTRACT:
Method for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic mammals harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.

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patent: 5387742 (1995-02-01), Cordell
Scheuner et al, Nature Medicine (Aug. 1996) 2: 864-870.
Games et al, Nature (Feb. 1995) 373: 523-527.
Farlow et al. Neurology (Jan. 1994) 44: 105-111.
Goate et al. Nature (1991) 349: 704-706.

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