Methods and vaccines comprising surface-active copolymers

Details Methods and vaccines comprising surface-active copolymers Methods and vaccines comprising surface-active copolymers

1995-04-11

1996-09-10

Housel, James C.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Synthetic polymer or copolymer

4242781, 4242831, 4242791, 514723, 5147723, A61K 4500, A61K 4730

Patent

active

055543723

ABSTRACT:
The present invention comprises adjuvants which, when admixed with an antigen and administered into a human or animal, will induce a more intense immune response to the antigen than when the antigen is administered alone. In many cases, the adjuvant that is described as the present invention will increase overall titer of antibodies of a specific isotype which are specific for the antigen. For example, in mice, when the adjuvant of the present invention is admixed with a conventional antigen, the isotype that is induced in the mouse is changed from a predominantly IgG1 isotype to the more protective IgG2 isotype and, in some cases, IgG3 isotype. Thus, by practicing the present invention, one can improve the overall protective effect of conventional vaccines.

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