Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones ha

Details Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones ha Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones ha

1987-11-17

1989-08-01

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, 514343, 514336, 514346, 514350, 546262, 546263, 546278, 546281, 546283, 546284, 546292, 546297, 546298, C07D40312, C07D, C07D, C07D40912, A61K 3144

Patent

active

048533955

ABSTRACT:
Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.

REFERENCES:
patent: 4567186 (1986-01-01), Lesher et al.
patent: 4568751 (1986-02-01), Jones et al.
patent: 4650806 (1987-03-01), Lesher et al.
Chem. Abstracts, vol. 106 (25) Abst. No. 213,774z, Jun. 22, 1987.

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